Effects of N-acetylcysteine on lung glutathione levels in rats after burn injury

Konukoglu D., Cetinkale O., Bulan R.

Burns, cilt.23, ss.541-544, 1997 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0305-4179(97)00059-4
  • Dergi Adı: Burns
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.541-544
  • Anahtar Kelimeler: burn, lipid peroxidation, malondialdehyde, glutathione, N-acetylcysteine, LIPID-PEROXIDATION, FREE-RADICALS, SKIN
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

This study was designed to determine the effect of N-acetylcysteine (NAC, a natural hydroxyl radical scavenger) treatment on levels of pulmonary malondialdehyde (MDA, the end product of lipid peroxidation) and glutathione (GSH, a natural antioxidant) in thermally injured rats. Severe skin scald injury (30 percent TBSA) caused a significant decrease in GSH levels, and a significant increase in MDA levels in lung tissue both at 1 hr and 1 day postburn injury. Treatment of rats with NAC (15 mg/kg intraperitoneally, 15 min and 12 hr following the burn) significantly improved GSH levels, and decreased ongoing lipid peroxidation at 1 day. This study showed that thermal injury resulted in increased pulmonary lipid peroxidation, and this remote organ injury was decreased by treatment with NAC. In addition NAC, a scavenger of hydroxyl radicals, improved GSH levels in lungs. The higher level of GSH in the lungs of the burned rats treated with NAC could be due to either a decrease in the rate of degradation of GSH or to an increase in its synthesis. No data about these possibilities are provided.