Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine
CEPHALALGIA, cilt.38, sa.11, ss.1773-1781, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 11
- Basım Tarihi: 2018
- Doi Numarası: 10.1177/0333102417748928
- Dergi Adı: CEPHALALGIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1773-1781
- Anahtar Kelimeler: Chronic migraine, non-obese female, glucagon-like peptide-1, insulin resistance, neuropeptide Y, -cell function, BETA-CELL FUNCTION, VASCULAR RISK-FACTORS, NEUROPEPTIDE-Y, SENSITIVITY, SECRETION, ASSOCIATION, ACTIVATION, HYPOTHALAMUS, HOMEOSTASIS, INCREASES
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic -cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals. We studied the relationship of fasting neuropeptide Y with insulin resistance, -cell function, and glucagon-like peptide-1 secretion in non-obese female chronic migraine patients. We also aimed to investigate glucose-stimulated insulin and glucagon-like peptide-1 secretions as early pathogenetic mechanisms responsible for the development of carbohydrate intolerance.