Circulating nuclear factor-kappa B mediates cancer-associated inflammation in human breast and colon cancer.

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Papila K. B., Sozer V., Cigdem K. P., Durmus S., Kurtulus D., Papila C., ...More

Journal of medical biochemistry, vol.40, no.2, pp.150-159, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5937/jomb0-27128
  • Journal Name: Journal of medical biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.150-159
  • Keywords: nuclear factor kappa-B, tumour necrosis factor-alpha, soluble TNF-related apoptosis-inducing ligand, interleukin-6, pentraxin-3, APOPTOSIS-INDUCING LIGAND, C-REACTIVE PROTEIN, PENTRAXIN 3, COLORECTAL-CANCER, TNF-ALPHA, INTERLEUKIN-6, PATHWAY, EXPRESSION, PROGNOSIS, SURVIVAL
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Inflammation is recognized as a hallmark feature of cancer development and progression. The aim of our study was to investigate the significance of serum nuclear factor kappa-B (NF-k beta) levels as a circulating marker in the monitoring of inflammation in breast and colon cancer; to show the relationship between NF-kB with inflammatory parameters as tumour necrosis factor-alpha (TNF-alpha), soluble TNF-related apoptosis-inducing ligand (sTRAIL), interleukin-6 (IL-6), pentraxin-3 (PTX-3), procalcitonin (PCT), and C-reactive protein (CRP) levels.