Neuronal nitric oxide synthase expression in glial tumors: correlation with malignancy and tumor proliferation

Tanriover N., Ulu M. O., Isler C., Durak H., Oz B., Uzan M., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.30, sa.9, ss.940-944, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1179/174313208x319099
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.940-944
  • Anahtar Kelimeler: Glial tumor, malignancy, nitric oxide, nitric oxide synthase, tumor proliferation, HUMAN BRAIN-TUMORS, GLIOMA, LOCALIZATION, GENE, VASCULATURE, INDUCTION, CANCER, INJURY, CELLS, FLOW
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Introduction: Increased vascular permeability, vasodilatation, neovascularization and free radical injury in malignant tumors and adjacent normal tissues are believed to be mediated by nitric oxide (NO). High levels of neuronal nitric oxide synthase (nNOS) have been demonstrated in cultured and intracerebral cells. Our aim was to investigate nNOS expression in human glial tumors and to assess its correlation with the histologic grade and proliferative potential.