Dysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia

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Firtina S., Hatirnaz Ng O., ERBİLGİN Y., ÖZBEK U., SAYİTOĞLU M.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.1, pp.357-363, 2017 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1507-106
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.357-363
  • Keywords: B-cell acute lymphoblastic leukemia, methylation, beta-catenin, DKK1, WNT pathway, WNT ANTAGONIST DICKKOPF-1, EPIGENETIC INACTIVATION, MULTIPLE-MYELOMA, BREAST-CANCER, STEM-CELLS, IN-VIVO, HYPERMETHYLATION, EXPRESSION, FAMILY
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background/aim: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the beta-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6.