Dysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia

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Firtina S., Hatirnaz Ng O., ERBİLGİN Y., ÖZBEK U., SAYİTOĞLU M.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.1, ss.357-363, 2017 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1507-106
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.357-363
  • Anahtar Kelimeler: B-cell acute lymphoblastic leukemia, methylation, beta-catenin, DKK1, WNT pathway, WNT ANTAGONIST DICKKOPF-1, EPIGENETIC INACTIVATION, MULTIPLE-MYELOMA, BREAST-CANCER, STEM-CELLS, IN-VIVO, HYPERMETHYLATION, EXPRESSION, FAMILY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background/aim: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the beta-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6.