The effects of rapid and slow infusion of fluid on coagulation factors in hemorrhagic shock: An experimental dogs model Hemorajik şokta hizli ve yavaş sivi infüzyonunun koagülasyon faktörleri üzerine etkisi: Köpekte deneysel çalişma
Ulusal Travma ve Acil Cerrahi Dergisi, cilt.12, sa.2, ss.95-100, 2006 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 2
- Basım Tarihi: 2006
- Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.95-100
- Anahtar Kelimeler: Blood coagulation, Blood transfusion, Dogs, Fluid therapy/adverse effects/methods, Infusions, Resuscitation, Ringer's lactate, Shock, hemorrhagic/blood/ pathology, Survival rate
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
BACKGROUND: The diagnosis of hemorrhagic shock in a patient with tachycardia and hypotension is generally straightforward. The difficulty lies in the selection of optimal approach for the patient. In this study on a canine model of deep hemorrhagic shock induced by bleeding, we used various amounts of fluid infusion to determine the most appropriate amount of fluid resuscitation. METHODS: The study included 30 mongrel dogs. Mongrel dogs were randomized to three equal groups of 10. The control group received no treatment. The rapid infusion group received 60 mL/kg of lactated Ringer's solution in half an hour whereas the third group received 30 mL/kg during the same time period. RESULTS: The lactate decreased in the two treatment groups. The platelet and fibrinogen levels did not vary in the slow infusion group but decreased markedly in the rapid infusion group. CONCLUSION: In conclusion, fluid resuscitation should not be unnecessarily aggressive. The coagulation parameters are diluted in proportion with the amount of fluid given. Blood lactate level can be used as a guiding marker in evaluation of treatment effectiveness of hemorrhagic shock patients.