Severity scores, damage indices, and the concept of the colchicine-resistant patient in familial Mediterranean fever

Er O., Akay H., Ozgozen M. E., Gulhan D., UĞURLU S.

MODERN RHEUMATOLOGY, sa.1, ss.7-16, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1093/mr/roae067
  • Dergi Adı: MODERN RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, MEDLINE
  • Sayfa Sayıları: ss.7-16
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Familial Mediterranean fever is a common autoinflammatory disease. The primary treatment is colchicine; however, 5-10% of patients do not respond to colchicine and are considered colchicine resistant. Colchicine resistance and disease severity are highly associated, with each used to assess and define the other. In our review, we examined the most commonly used severity scores, damage indices, and definitions of colchicine resistance, revealing both shortcomings and advantages for each. We emphasize the necessity for a new severity score that integrates the definition of colchicine resistance.