Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review


Filik H., Avan A. A. , Özyürek M.

CURRENT MEDICINAL CHEMISTRY, vol.28, no.20, pp.4023-4048, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 20
  • Publication Date: 2021
  • Doi Number: 10.2174/0929867328666201124151821
  • Title of Journal : CURRENT MEDICINAL CHEMISTRY
  • Page Numbers: pp.4023-4048
  • Keywords: Prostate-specific antigen, cancer marker, immunosensor, immunoassay, nanomaterial, nanotechnology, HIGHLY SENSITIVE DETECTION, TRIPLE SIGNAL AMPLIFICATION, METAL-ORGANIC FRAMEWORK, CORE-SHELL, GOLD NANOPARTICLES, GRAPHENE OXIDE, ULTRASENSITIVE DETECTION, CARBON NANOTUBES, RECENT PROGRESS, QUANTUM DOTS

Abstract

The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This survey shows recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate- specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.