The relation between the sex hormone receptors and hormones in children with bladder dysfunction and VUR: Clinical preliminary report Mesane işlev bozukluǧu ve vezikoüreteral reflüsü olan çocuklarda cinsiyet hormonu - Almaç ilişkisi (klinik ön bildiri)

Akova F., CELAYİR R. S., Dervişoǧlu S., Emir H., SÖYLET Y., Büyükünal S. N. C., ...Daha Fazla

Pediatrik Cerrahi Dergisi, cilt.17, sa.3, ss.120-127, 2003 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2003
  • Dergi Adı: Pediatrik Cerrahi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.120-127
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background/aim: This study aims to clarify to role of the sex hormone receptors and sex hormones in bladder neck disorders in children. In this study we investigated patients with bladder dysfuntion and VUR in regard to existence and location of sex hormone receptors in bladder and sex hormone levels. Methods: The study consists of three groups. Group-1: Patients with non-neuropathic bladder-sphincter disfunction (n=10). Group-11: Patients with neuropathic bladder-sphincter disfunction (n=6). Group-111: Patients with vesicoureteral reflux (n=9). Biopsies were taken during open surgery and/or cystoscopic procedures for various indications from the trigonum and bladder dome. All biopsies were routinely fixed and processed for histopathological assessment and investigated immunohistochemically for determination of sex hormone receptors (estrogen, androgen and progesterone) in bladder. All sex hormone levels were evaluated and compared according to age of patients. Results: This study included 44 bladder biopsies of total 25 children. Male: female ratio was 16: 9. Overall receptor positivity was found 6,8% in estrogen; 40,9% in androgen and 50% in progesterone. Deeper tissues were examined in 26 (59%) biopsies. The sex hormone receptors were present only in transitional epithelium and there was no receptor expression in deeper tissues of bladder wall. Sex hormone levels in ostradiol (E2) was high in 8 (34,7%), low in 4 (17,3%) and normal in 11 (48%) patients. Testosterone levels were found high in 3 (13%), low in 6 (26%) and normal in 14 (61%) patients. Progesteron levels were found high in 17 (73%) and normal in 6 (27%) patients. There was no significant difference between the study groups in regard to receptor and hormone levels. Conclusion: Sex hormone receptors are present in children. The receptors are present mainly localized at bladder neck and in transitional epithelium of the bladder wall. The sex hormone receptors were found in different density and ratio in both of gender and groups. The sex hormone levels also varied in different gender and groups.