The importance of Lp(a)-fibronectin interaction in atherogenesis

Sonmez H. A., Suer S., Kokoglu E., Dirican A., Ulutin T., Ucisik N., ...Daha Fazla

HAEMATOLOGIA, cilt.28, sa.3, ss.149-153, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 1997
  • Dergi Adı: HAEMATOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.149-153
  • Anahtar Kelimeler: fibronectin, Lp(a), coronary heart disease, CORONARY-ARTERY DISEASE, LOW-DENSITY-LIPOPROTEIN, PLASMA FIBRONECTIN, MYOCARDIAL-INFARCTION, RISK FACTOR, LP(A), DEGRADATION, EXPRESSION, MATRIX, WALL
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

An elevated concentration of lipoprotein (a) (Lp(a)) in serum has been considered a risk factor for coronary heart disease by various investigators. The apo(a) portion of Lp(a) binds to the carboxyterminal heparin binding domain of fibronectin. Lp(a) bound to fibronectin is internalized through the fibronectin receptor pathway and thereby causes increased accumulation of lipid and foam cell formation. In the present study, fibronectin and Lp(a) concentrations have been assayed in patients with coronary heart disease (CHD) and healthy subjects.