Akademik Veri Yönetim Sistemi
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, cilt.50, sa.3, ss.1001-1015, 2024 (SCI-Expanded, Scopus)
Objective: Naphthoquinones are compounds that are common in nature which have biological activity depending on the attachment of new substituted groups. Methods: In the present study, the inhibition effects of newly synthesized naphthoquinones derivatives (I), (IIa-IId) on alpha-glucosidase, alpha-amylase, xanthine oxidase, and trypsin and antioxidant properties were investigated by in vitro studies. Results and Discussion: The synthesized compounds (IIb) (784.04 +/- 79.95 mu M) and (IId) (477.55 +/- 1.18 mu M) compounds on alpha-glucosidase activity were found to have a lower IC50 value when compared to the positive control-acarbose (1628.48 +/- 32.89 mu M) as well as molecular docking results. Compound (IId) (690.45 +/- 5.48 mu M) had high 2,2-diphenyl-1-picrylhydrazil (DPPH) scavenging activity, with an IC50 value lower than that of the positive control butylated hydroxytoluene (BHT, 961.92 +/- 6.41 mu M). The results indicated that synthesized compounds had a dose-dependent inhibition effect on the enzymes. Conclusions: In the in vitro studies, compounds (IIb) and (IId) were strong alpha-glucosidase inhibitors as well as compound (IId) had high DPPH scavenging activity.