B-TYPE NATRIURETIC PEPTIDE (BNP) IN MODERATE TO SEVERE BRONCHIOLITIS

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Kes G.

The 7th Congress of the European Academy of Pediatric Societies, Paris, France, 31 October - 03 November 2018, vol.1, no.1, pp.4, (Summary Text)

  • Publication Type: Conference Paper / Summary Text
  • Volume: 1
  • City: Paris
  • Country: France
  • Page Numbers: pp.4
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

G. Kes (Turkey), G.E. Besli (Turkey), Y.I. Ayhan (Turkey), N. Erol (Turkey), F.K. Isman (Turkey)


Background and Aims

The aim of this study was to determine basal serum B-type natriuretic peptide (BNP) levels and its relationship with left ventricular systolic functions (LVSFs) and prognosis in patients hospitalized with moderate to severe bronchiolitis.

Method

The study was conducted prospectively on 37 patients between 1-24 months of age and diagnosed with bronchiolitis having modified Wang respiratory score of ≥6. Basal serum BNP levels and LVSFs of the patients were compared with control group. The patients with high (>100 pg/ml, n=6) and normal (≤100 pg/ml, n=31) BNP levels were compared regarding LVSFs, and vital, laboratory, and radiological findings. The relationship between BNP levels and prognosis was evaluated.

Results

The mean BNP level of the study group (61.75 ± 65 pg/ml) was higher than the control group (13.99±8.79 pg/ml) (p: 0.001). BNP level of 6 out of 37 patients was higher than 100 pg/ml. There was no significant difference between the patients with normal and high BNP level and control group regarding ejection fraction (EF) and fractional shortening (FS) values of echocardiography (p>0.05). Patients with high BNP level had higher mean pCO2 values than patients with normal BNP levels (p:0.037). There was a positive correlation between BNP level and hospital stay (r: 0.286; p: 0.007) and intensive care unit stay (r: 0.645; p: 0.000).

Conclusion

It is argued that increased serum BNP levels may be related to pulmonary involvement and the degree of deterioration of gas exchange in patients having bronchiolitis without myocardial dysfunction. Serum BNP level might be a potential prognostic factor in bronchiolitis.