Attenuation of ischemia/reperfusion injury by N-acetylcysteine in a rat hind limb model
JOURNAL OF SURGICAL RESEARCH, cilt.111, sa.2, ss.236-239, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 111 Sayı: 2
- Basım Tarihi: 2003
- Doi Numarası: 10.1016/s0022-4804(03)00094-5
- Dergi Adı: JOURNAL OF SURGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.236-239
- Anahtar Kelimeler: N-acetylcysteine, ischemia/reperfusion injury, dimethyl sulfoxide, thiobarbituric acid reactive substances, histological examination, ISCHEMIA-REPERFUSION INJURY, ACETYL-L-CYSTEINE, SKELETAL-MUSCLE
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Background. Ischemia/reperfusion is a complex set of events with severe pathologic consequences. Reperfusion initiates both the local and systemic damage in part through rapid oxygen generation. N-acetylcysteine (NAC) is a scavenger of free radical species, inhibits neutrophil accumulation, acts as a vasodilator and also improves microcirculation. In present study, we examined the protective effect of NAC in a rat hind limb ischemia/reperfusion model. Dimethyl-sulfoxide (DMSO), a well-known antioxidant was also tested for comparison.