Glutathione and malonyldialdehyde levels of liver, kidney and abdominal aorta tissues in STZ-diabetic rats administered gliclazide GLIKLAZID UYGULANAN STZ-DIABETIK SICANLARIN KARACIGER, BOBREK VE ABDOMINAL AORTA DOKULARININ GLUTATYON VE MALONDIALDEHID DUZEYLERI

Konukoglu D., Celik C., Akcay T., Hatemi H.

Klinik Gelisim, cilt.8, sa.3, ss.3566-3569, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 1995
  • Dergi Adı: Klinik Gelisim
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.3566-3569
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

In order to investigate the antioxidative effect of an oral anti-diabetic drug, gliclazide, on liver, kidney and abdominal aorta we applied peroral gliclazide for 29 days to the eighth of STZ-diabetic rats. We applied nothing to the remaining part of the STZ-diabetic rats (n:8). At the end of the procedure, the tissue glutathione (GSH) and malonyldialdehyde (MDA) levels of both the diabetic groups were compared to the levels of central group (n:5). The antioxidative effect of gliclazide on liver could be determined after 29 days of treatment with decrease in GSH and MDA levels whereas it was seen that these levels of abdominal aorta keep on being high. These biochemical parameters of oxidative stress in kidney did not differ from that of the control group. In conclusion, 29 days of treatment with gliclazide does not effectively protect the liver and kidney against the oxidative stress of diabetes.