Small Molecule, Multimodal, [F-18]-PET and Fluorescence Imaging Agent Targeting Prostate-Specific Membrane Antigen: First-in-Human Study

Aras, Omer; DEMİRDAĞ, ÇETİN; Kommidi, Harikrishna; Guo, Hua; Pavlova, Ina; AYGÜN, Aslan; KARAYEL, EMRE; Pehlivanoglu, HÜSEYİN; YEYİN, NAMİ; Kyprianou, Natasha; Chen, Nandi; Harmsen, Stefan; SÖNMEZOĞLU, KERİM; Lundon, Dara; Oklu, Rahmi; Ting, Richard; Tewari, Ashutosh; Akin, Oguz; SAYMAN, HALUK

doi:10.1016/j.clgc.2021.03.011

Small Molecule, Multimodal, [F-18]-PET and Fluorescence Imaging Agent Targeting Prostate-Specific Membrane Antigen: First-in-Human Study

Aras O., DEMİRDAĞ Ç., Kommidi H., Guo H., Pavlova I., AYGÜN A., ...Daha Fazla

CLINICAL GENITOURINARY CANCER, cilt.19, sa.5, ss.405-416, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 5
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.clgc.2021.03.011
Dergi Adı: CLINICAL GENITOURINARY CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
Sayfa Sayıları: ss.405-416
Anahtar Kelimeler: Image-guided surgery, Positron emission tomography, Prostate cancer, PSMA, PET imaging, RADICAL PROSTATECTOMY, PET
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

A number of radioactive tracers are currently being actively examined to image prostate-specific membrane antigen positive (PSMA+) tumors, especially in primary and recurrent prostate cancer. We report a first-in-human study of [18F]-BF3-Cy3-ACUPA by determining its safety, biodistribution, radiation dosimetry, and feasibility of tumor detection by preoperative positron emission tomography, as well as intraoperative fluorescence imaging, in patients with PSMA+ tumors.