Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients

Bayoglu B., Yuksel H., Cakmak H. A., Dirican A., Cengiz M.

CLINICAL BIOCHEMISTRY, vol.49, no.10-11, pp.821-827, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 10-11
  • Publication Date: 2016
  • Doi Number: 10.1016/j.clinbiochem.2016.02.012
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.821-827
  • Keywords: Hypertension, Chromosome 9p21.3, CDKN2A/B, CDKN2B-AS1, Genetic variation, Haplotypes, GENOME-WIDE ASSOCIATION, PERIPHERAL ARTERY-DISEASE, CHROMOSOME 9P21, TUMOR-SUPPRESSOR, RISK, EXPRESSION, LOCUS, ANRIL, IDENTIFICATION, METAANALYSIS
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Objectives: Hypertension (HT) is a complex disorder influenced by both genetic and environmental factors. Recent genome-wide association studies have identified a major risk locus for atherosclerosis on chromosome 9p21.3. SNPs within the coding sequences of CDKN2A/B and the long non-coding RNA CDKN2B-AS1 could potentially contribute to HT development. Thus, this study aimed to investigate whether the frequency of four SNPs on chromosome 9p21.3 affects blood pressure (BP) levels in Turkish HT patients, and to examine correlations between these SNPs, specific SNP haplotypes, and HT.