Trial of Apremilast for Oral Ulcers in Behcet's Syndrome

Hatemi G., Mahr A., Ishigatsubo Y., Song Y., Takeno M., Kim D., ...Daha Fazla

NEW ENGLAND JOURNAL OF MEDICINE, cilt.381, sa.20, ss.1918-1928, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 381 Sayı: 20
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1056/nejmoa1816594
  • Dergi Adı: NEW ENGLAND JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1918-1928
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

BackgroundThe small-molecule phosphodiesterase 4 inhibitor apremilast modulates cytokines that are up-regulated in Behcet's syndrome. In a phase 2 trial involving patients with Behcet's syndrome, apremilast reduced the incidence and severity of oral ulcers. Data on the efficacy and safety of apremilast in patients with Behcet's syndrome who had active oral ulcers and had not previously received biologic agents are limited.