Usefulness of the epithelial tumor marker CA-125 in non-Hodgkin's lymphoma

Ozguroglu M. , Turna H. , Demir G., Doventas A. , Demirelli F. H. , Mandel N. K. , ...More

American Journal of Clinical Oncology: Cancer Clinical Trials, vol.22, no.6, pp.615-618, 1999 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 1999
  • Doi Number: 10.1097/00000421-199912000-00014
  • Title of Journal : American Journal of Clinical Oncology: Cancer Clinical Trials
  • Page Numbers: pp.615-618


CA-125, a commonly used tumor marker for epithelial ovarian cancer, is a glycoprotein found in normal tissues derived from coelomic epithelia. Increased serum levels of CA-125 have also been found in nongynecologic tumors and nonmalignant diseases involving the peritoneum. A few recent studies and sporadic case reports have reported increased CA-125 levels in patients with non-Hodgkin's lymphoma (NHL). In our study, we aimed to evaluate the serum levels of CA-125 in patients with NHL and determine its potential role to show disease activity in NHL. Serum levels of CA-125 were measured in 61 patients with NHL and were found to be correlated with clinical stage, site of involvement, and disease activity.