Akademik Veri Yönetim Sistemi
5th Regional TIAFT Meeting, Diyarbakır, Türkiye, 9 - 11 Ekim 2024, ss.6, (Özet Bildiri)
Determination of The Presence of Opiates in Urine and Underwears Samples of People Who Consumed Poppy Seed Buns
Cenk BULUT, Zeynep ARSLAN, Zeynep TURKMEN
Istanbul University-Cerrahpaşa, The Institute of Forensic Sciences and Legal Medicine,
Department of Science, Istanbul, Türkiye
Poppy seed ingestion is known to cause positive opioid drug tests, and many false-positive studies have been reported in the scientific literature over the past 20 years.
Forensic toxicologists appear to be seeking alternatives to distinguish between heroin administration and natural opioid ingestion through natural poppy consumption. Most of the studies conducted concern the exclusion of illicit heroin use by testing biological matrices for the presence of acetylcodeine, thebaine, papaverine, noscapine and their associated metabolites.
Sweat is an alternative biological matrix useful for the detection of drugs of abuse. It is produced by eccrine and apocrine glands that originate in the dermis and terminate in secretory ducts that drain to the skin surface and hair follicles. It has been shown for many years that endogenous and exogenous chemicals are secreted in this biological sample, so its collection and analysis can indicate past intake of xenobiotics.
In this context, the aim of this study was to interpret urine and sweat samples from a group of volunteers who had consumed a controlled amount of poppy seeds.
A method was developed to analyse the opioids from both matrices and the results were compared at 6, 12 and 24 hours after consumption.
Keywords: Urine, Sweat, Opioids, Poppy seeds, LC-MS/MS, controlled administration