Akademik Veri Yönetim Sistemi
6th International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2025) (Online), Ankara, Türkiye, 25 - 27 Haziran 2025, ss.1471, (Özet Bildiri)
Abstract
Aldose reductase (AR, E.C.1.1.1.21) enzyme is a cytosolic NADPH-dependent oxidoreductase that catalyzes the conversion/reduction of glucose to sorbitol in the first step of the polyol pathway of glucose metabolism. During hyperglycemia, aldose reductase enzyme activity is high in renal glomerular and tubular cells, peripheral nervous system and retinal tissue, and long-term diabetic complications such as nephropathy, neuropathy and retinopathy occur. Aldose reductase enzyme catalyzes the reduction of various compounds such as lipids, aldehydes, phospholipids, atherogenic aldehydes and steroids, mediates the transmission of signals initiated by cytokines, chemokines, growth factors, endotoxins and allergens, and creates disorders in tissue metabolism. As a result of this situation, various cancers such as breast, colon, liver, lung, prostate and ovarian cancer may develop in the body. Many different aldose reductase inhibitors are not used clinically due to some side effects in order to delay or prevent the development of diabetic complications and various cancers.Therefore, studies are ongoing to investigate aldose reductase inhibitors with fewer side effects. In this study, the inhibitory effects of plant extracts and some metal salts on the aldose reductase enzyme were examined. It was found that the plant extracts of pumpkin, grapefruit and aqueous chard extracts and the metal salts of iron (II) sulfate, copper (II) sulfate, iron (III) sulfate and sodium valproate inhibited the AR enzyme at a high level. It can be suggested that the plant extracts and metal salts with high AR inhibition can be used in addition to drug treatment in delaying the development of diabetic complications and various types of cancer due to their low side effects.