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Turk Anesteziyoloji ve Reanimasyon, vol.25, no.3, pp.100-105, 1997 (Scopus)
The experiments were conducted in anesthetized dogs (Na thiopentone IV). Tidal volume (V(T)), respiratory frequency (f/min), systemic arterial blood pressure (AP) were recorded. The central effects of capsaicin, veratrine, histamin, and bradykinin were investigated by injection of these substances directly into the cerebrospinal fluid by atlanto-occipital punction. The peripheral effects of the same substances were studied after in IV injections. Both central and peripheral application of capsaicin caused an increase in f. An initial decrease which was followed by a significant increase was observed in V(T). After vagotomy the peripheral effect in V(T) was abolished but the central response was uneffected. Central application of capsaicin increased whereas peripheral application decreased AP. After vagotomy both central and peripheral application of capsaicin caused increase in AP. Histamin application centrally and peripherally increased f and V(T). After vagotomy peripheral application was uneffective. Veratrine caused similar respiratory responses as capsaicin. Both central and peripheral application of bradykinin increased V(T). After vagotomy, V(T) response to peripheral application of bradykinin was abolished. It is concluded that the respiratory response to peripheral application of capsaicin and veratrin is vagally mediated and is due to stimulation of lung receptors. On the other hand these non-neural substance, when applied centrally, act directly on the respiratory neurons and change their activity.