PTEN loss is a predictive marker for HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies

Tekesin, Kemal; Akar, Emre; Gunes, Mehmet; Bayrak, Savas; ÖZTÜRK, TÜLİN; Altinay, Serdar; Tural, Deniz

PTEN loss is a predictive marker for HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies

Tekesin K., Akar E., Gunes M. E. , Bayrak S., ÖZTÜRK T. , Altinay S., ...More

JOURNAL OF BUON, vol.24, no.5, pp.1920-1926, 2019 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 24 Issue: 5
Publication Date: 2019
Title of Journal : JOURNAL OF BUON
Page Numbers: pp.1920-1926

Abstract

Purpose: The purpose of this study was to retrospectively investigate the response to trastuzumab in breast cancer patients in terms of the potential roles of several oncogenic pathways (phosphatase and tensin homolog (PTEN) and phosphatidylinositol 3-kinase (PI3K)) in relation to HER2 status.