Chromosomal and microsatellite instability in sporadic gastric cancer

Hiyama, T; Tanaka, S; Yoshihara, M; Sasao, S; Kose, K; Shima, H; Tuncel, HANDAN; Ueno, Y; Ito, M; Kitadai, Y; Yasui, W; Haruma, K; Chayama, K

doi:10.1111/j.1440-1746.2004.03369.x

Chromosomal and microsatellite instability in sporadic gastric cancer

Hiyama T., Tanaka S., Yoshihara M., Sasao S., Kose K., Shima H., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.19, sa.7, ss.756-760, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 7
Basım Tarihi: 2004
Doi Numarası: 10.1111/j.1440-1746.2004.03369.x
Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.756-760
Anahtar Kelimeler: chromosomal instability, gastric cancer, genomic instability, microsatellite instability, REPLICATION ERROR PHENOTYPE, GENE, P53, HETEROZYGOSITY, EXPRESSION, MUTATIONS, STOMACH, MARKER
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: Gastric cancer can progress through two pathways of genomic instability: chromosomal (CIN) and microsatellite instability (MSI). It is hypothesized that these two pathways are not always independent and that some tumors show overlap between these two mechanisms.