Effect of Radiation Exposure Duration on the Microwave-Assisted Synthesized Sr2+ Doped β-Tri-Calcium Phosphate Powders

Yelten Coşkun A., Ercan B.

3rd International Graduate Research Symposium (IGRS'24), İstanbul, Turkey, 8 - 10 May 2024, pp.406, (Summary Text)

  • Publication Type: Conference Paper / Summary Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.406
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Biomaterials can be classified depending on the type of material-tissue responses. These can be defined as bioinert, bioactive, and bioresorbable. Likewise, bioceramics, an essential type of biomaterials, can be divided into groups considering the same approach. β-Tri-calcium phosphate (Ca3(PO4)2, β-TCP, Whitlockite) is a well-known bioresorbable bioceramic material that can be used in applications such as hard tissue filling, tissue scaffolds, and bone grafts for fractures or defects. β-TCP promotes the bone regeneration process due to its ability to enable bone-like tissue growth on its surface which indicates its bioactive and osseoconductive properties. Hence, β-TCP helps to reduce the healing duration by supporting osseointegration. β-TCP can be prepared in different forms like putty, graft, granules, or powders. Among several methods such as wet chemical precipitation, sol-gel, hydrothermal processes, etc. microwave-assisted synthesis technique draws interest thanks to its advantages, which can be stated as being rapid and practical, working with fewer process parameters, enabling more uniform and submicron-sized particles. Sr2+ is reported to have a two-way biological effect. Namely, it stimulates the new bone tissue formation and lowers the bone resorption risk during the implantation procedure. In this context, non-doped and Sr2+ doped β-TCP powders were obtained through microwave-assisted synthesis by implementing microwave radiation for different times, i.e. 5 min, 10 min, and 15 min. Preparation of the Ca and P precursor solutions, the reaction between these source solutions in a household-type modified microwave oven, centrifuging & washing, drying, and finally calcination at 900 °C for 1h were realized sequentially. The chemical phase, microstructure, and in-vitro bioactivity properties of the acquired powders were investigated by conducting x-ray diffraction (XRD), scanning electron microscope (SEM), and simulated body fluid (SBF) immersion tests for 14 days at 37 °C, respectively. The particle size of the Sr2+ doped β-TCP powders tends to decrease with the increasing microwave radiation exposure duration.