Extractive-spectrophotometric determination of amine-type stimulants and antidepressants with anionic indicator dyes
JOURNAL OF ANALYTICAL CHEMISTRY, cilt.68, sa.7, ss.583-589, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 7
- Basım Tarihi: 2013
- Doi Numarası: 10.1134/s1061934813070046
- Dergi Adı: JOURNAL OF ANALYTICAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.583-589
- Anahtar Kelimeler: antidepressant amines, amphetamine, ecstasy, sibutramine, ion-pair extraction, spectrophotometry, PERFORMANCE LIQUID-CHROMATOGRAPHY, FLUOXETINE HYDROCHLORIDE, GAS-CHROMATOGRAPHY, METHYLENEDIOXYLATED AMPHETAMINES, SIBUTRAMINE HYDROCHLORIDE, DRUGS, PHARMACEUTICALS, METABOLITES, ECSTASY, SAMPLES
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Amphetamines having a stimulant effect on the central nervous system, certain antidepressants, and slimming agents containing sibutramine bear the cationic amine constituents that can form colored ion-association complexes with anionic basic dyes (i.e. bromocresol purple (BCP), methyl orange (MeO), and eriochrome black-T (EBT)), and be extracted into organic solvents for spectrophotometric determination. The limit of detection (LOD, mg/L) of the tested amines varied within the following intervals: MDMA: 0.09-0.33; MDA: 0.14-1.43; fluoxetine: 0.09-0.24; sibutramine: 0.07-0.28, depending on the dye. The proposed rapid and cost-effective extractive-photometric method for MDMA, fluoxetine, and sibutramine was statistically validated against HPLC using ecstasy, prozac, and lida pharmaceutical tablets.