Kruppel-Like Transcription Factor-4 Gene Expression and DNA Methylation Status in Type 2 Diabetes and Diabetic Nephropathy Patients

Coskun, Zeynep; Ersoz, Melike; Adas, Mine; HANÇER, VEYSEL; Boysan, Serife; Gonen, MUSTAFA; Acar, Aynur

doi:10.1016/j.arcmed.2019.05.012

Kruppel-Like Transcription Factor-4 Gene Expression and DNA Methylation Status in Type 2 Diabetes and Diabetic Nephropathy Patients

Coskun Z. M., Ersoz M., Adas M., HANÇER V. S., Boysan S. N., Gonen M. S., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.50, sa.3, ss.91-97, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 50 Sayı: 3
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.arcmed.2019.05.012
Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.91-97
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background/Aim. Diabetic nephropathy (DN) is one of the most serious microvascular complications in diabetic patients. The kruppel-like transcription factor-4 (KLF-4) affects the expression of genes involved in the pathogenesis of DN. The present study aims to identify the KLF-4 expression and DNA methylation (DNAMe) status in patients with type-2 diabetes (T2D) and DN and to reveal the contribution of the KLF-4 to the development of DN.