Research Information System
in: Molecular Basis and Emerging Strategies for Anti-aging Interventions, Syed Ibrahim Rizvi &Ufuk Çakatay, Editor, Springer, London/Berlin , Singapore, pp.373-386, 2018
Aging is a series of progressive
degenerative body changes associated with decreased physiological functionality
and a decline in the ability to adapt to metabolic stress. Geroscience
particularly focuses on understanding the mechanisms of aging and multiple
genetic and pharmacological therapies which have been developed in order to
modulate the pace of natural aging and to prevent the age-related disorders
such as cancer, kidney diseases, cardiovascular disorders, and many others;
these geroprotective and senolytic interventions have shown to be beneficial
for extending the life span and delaying age-related functional declines in
rodents. Recent developments in geroscience also contributed to the improvement
of quality of life and the extension of expected life span of cats and dogs.
Like in humans, the life expectancy of cats and dogs varies significantly based
on racial disparities; breed is an important determinant of life expectancy in
pets. Other factors such as gender, genetics, environment, and stressors also
play an important role throughout the aging process. Use of geroprotective
agents by veterinarians is becoming more common day by day, extending the life
span of pets and contributing to the establishment of a more peaceful home
environment by decreasing the disease burden. This chapter will focus on the
use of these geroprotective and senolytic agents and their overall impact on
the prevention of age-related degenerative changes and disorders in companion
animals: cats and dogs.
Keywords
Aging Geroscience Longevity Life
span Quality of life Cat Dog