Akademik Veri Yönetim Sistemi
EUROPEAN GERIATRIC MEDICINE, cilt.5, ss.246-247, 2014 (SCI-Expanded, Scopus)
P518 A case of statin induced cough S. Yavuzer1, H. Yavuzer2, M. Cengiz1, S. Yadigar1, M. Yuruyen3, A. Doventas2, Y. Karter1 1Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul Univer, Istanbul, Turkey; 2Department of Geriatrics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; 3Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey Introduction: Asthma and chronic obstructive lung disease are known as the most common etiological agents of chronic coughing. Meanwhile statins have begun to participate in this classification causing interstitial lung disease (ILD). Case: A 85 year-old female patient was admitted with the complain of dry cough. She has been followed with the diagnoses of hypertension, hyperlipidemia, rheumatoid arthritis (RA). Pretibial oedema and two sided rales on the lower part of the lungs were detected. Hemogram and biochemical findings were normal. Two sided pleural effusion and pattern of interstitial oedema with an heart dilatation were detected (Figure 1). Global hypokinesis of left ventricle with an ejection fraction (EF) of 35% on echocardiography were seen. RA associated with interstitial lung disease and pulmonary toxicity of methotrexate were ruled out. Wedetected minimal bilateral pleural effusion and an increase from 35% to 50% in EF with normal physical signs except dry cough after three months. The statin usage was stopped. The patient relieved more significantly. The complete cure of the cough occurred. She had not used any antitussives. She had not used any antitussives. After the one year follow up pleural effusion was disappeared (Figure 2). Discussion: Fernandez et al. reported that 1–40/10,000 of the biopsy proven. The patients with ischemic heart disease seem more likely to developed statin induced ILD. The drug induced ILD should be considered in differential diagnosis after excluding common causes of chronic cough. Statin therapy should be discontinued at early stages to prevent progression to irreversible fibrosis.