Potential Drug-Drug Interaction Detection Using the UpToDate Mobile Application in Intensive Care: A Retrospective, Observational Study
TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI, cilt.23, sa.1, ss.61-69, 2025 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/tybd.galenos.2024.15045
- Dergi Adı: TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.61-69
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Objective: This study aimed to investigate the frequency of potential drug- drug interactions (pDDI) and the effect of the number of drugs used on pDDIs using the UpToDate drug interactions application. Materials and Methods: Patients aged >12 years who were treated in the intensive care unit for 3 days in 2016 were included in the study. pDDIs were detected by entering the drugs used for >24 hours into the UpToDate application. The total number of mild, moderate, and severe pDDIs, number of medications used, length of stay, age, number of chronic diseases, mechanical ventilation (MV) support, hospitalization diagnoses, and APACHE II score were statistically compared. Results: Although the pDDI was found to increase with the number of medications administered, it did not show an exact association with the number of days of hospitalization. However, it was higher among patients who received MV support, had a high APACHE II score, and died. pDDI was observed least in the postoperative follow-up group. Conclusion: The pDDI increased as the number of medications used by critically ill patients increased.