Citrullinated Histone H3 as a Biomarker in Sepsis and Critical Care
Biomarkers in Trauma, Injury and Critical Care, Rajendram,R.,Preedy,V.R.,Patel,V.B., Editör, Springer Nature, London, ss.1-21, 2022
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2022
- Yayınevi: Springer Nature
- Basıldığı Şehir: London
- Sayfa Sayıları: ss.1-21
- Editörler: Rajendram,R.,Preedy,V.R.,Patel,V.B., Editör
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Sepsis occurs when the body’s response to these chemicals is unbalanced and changes are triggered that can damage multiple organ systems. Histones are structures located in the cell nucleus and can be released into the bloodstream and tissues when the cell is damaged or during programmed cell death, with the formation of neutrophil extracellular traps. Citrullinated histone H3 level is associated with disease severity in the sepsis. Citrullinated histone H3 levels are correlated with the severity of septic shock. Neutrophil extracellular trap components and citrullinated histone H3 were detected in patients with resuscitation, intoxication, cerebrovascular accident, and heat stroke. Citrullinated histone H3 is considered the most specific NET marker due to the critical role of histone citrullination in NETosis.