Akademik Veri Yönetim Sistemi
6th International Turkic World Conference on Chemical Sciences and Technologies, Baku, Azerbaycan, 26 - 29 Ekim 2022, ss.27, (Tam Metin Bildiri)
Anthraquinones are distinctive chemical compounds that have been used in various therapeutic applications for centuries. Although it was obtained from the nature many years ago, its synthetic applications are not so old. Quinones and anthraquinones are excellent examples, especially when we look at nature for the development of therapeutic drugs. Anthraquinones are compounds in the cyclic diketone structure whose carbonyl functional group is located at the 9th and 10th carbon positions of the quinone moiety. Rigidity, flatness and aromaticity of the anthraquin ring encourage the study of pharmacological properties. In particular, the planarity of the molecule helps to act as DNA intercalator providing the advantage of embedding in the DNA double helix. Examples of anthraquinone core found in nature are emodin, aloe-emodin, rhein and crosophanol [1-4]. These types of compounds have been used as starting materials for the development of many anticancer agents. Anthraquinones are one of the important organic compounds found in some plants in nature, microorganisms and insects and formed metabolically in their structures.
Due to the colorful structures and biological activities of anthraquinones, they are used in many different fields from dyes to biological and medicinal products. [5,6]. Anthraquinones with various properties are given below (Figure 2). It exhibits antifungal [7], neurotherapeutic agent [8], the chemotherapeutic agent [9] fluorescent, chemosensory, phosphorescent properties [10,11]. In this study, synthesis studies were carried out by using 1-Chloroanthraquinone compound as a substance.The reactions of 1-chloroanthraquinone were carried out with various nucleophiles containing amno and thio groups. As a result of the reactions, amno- and thio-substituted anthraquinone derivatives were synthesized. 2 original products were synthesized, different properties of these products were determined.