Retrospective analysis of children with uveitis treated with infliximab

Tugal-Tutkun I., Ayranci O., Kasapcopur O., Kir N.

JOURNAL OF AAPOS, cilt.12, sa.6, ss.611-613, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jaapos.2008.08.007
  • Dergi Adı: JOURNAL OF AAPOS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.611-613
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Tumor necrosis factor-alpha (TNF-alpha) antagonists have been successfully used in refractory cases of pediatric uveitis.(1-7) We report our experience with the monoclonal anti-TNF-alpha antibody infliximab in the treatment of uveitis in 20 children. Twenty children with noninfectious uveitis were treated with infliximab as an initial line of immunomodulatory therapy (4 children) or for uncontrolled intraocular inflammation despite aggressive immunosuppressive therapy (16 children). Intraocular inflammation was controlled in the short term in all children; resistance developed in 4 children after long-term therapy.