PHYSICO-CHEMICAL CHARACTERIZATION AND ANTIBACTERIAL, ANTIFUNGAL AND ANTIVIRAL ACTIVITY OF TWO NEW BENZIMIDAZOLYLPHENOL DERIVATIVES AND THEIR COMPLEXES
Revue Roumaine de Chimie, sa.1-2, ss.89-101, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.33224/rrch.2026.71.1-2.10
- Dergi Adı: Revue Roumaine de Chimie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source
- Sayfa Sayıları: ss.89-101
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Two new chelating benzimidazolylphenol type ligands, 2-(6-tert-butyl-1H-benzimidazol-2-yl)-4,6-dichlorophenol (HL1) and 2,4-dichloro-6-(6-chloro-1H-benzimidazol-2-yl)phenol (HL2) were employed to create complexes (1a – 2e) with Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) ions. A variety of analytical and spectroscopic methods were utilized to verify the structures of the synthesized chelates, including elemental analysis,1H-NMR, UV-Vis spectroscopy, FT-IR, fluorescence spectroscopy, thermogravimetric analysis (TGA), magnetic moment and molar conductivity. The stoichiometry of the metal complexes was determined to be 1:2 M:L for Co(II) and Ni(II) complexes, while the Zn(II) and Pd(II) complexes exhibited a 1:1 M:L ratio. The antibacterial and antifungal activities of the compounds were tested against six bacteria and three fungi, and minimum inhibitory concentrations (MIC) values were obtained at the range of 39 – 1250 µg/mL. It was observed that HL2 (chloro derivative) showed slightly higher activity than HL1, while Ni(II), Zn(II) and Pd(II) complexes of both ligands were found to be more active against bacteria especially, compared to the ligands. Antiviral activity of the compounds was tested against Parainfluenza Type-2 virus. It was observed that HL1 showed higher antiviral activity than HL2 (antiviral property promoting effect of tert-butyl group) and the complexes showed higher antiviral activity than the ligands.