Köpeklerde derin kornea ülserlerinin tedavisinde otolog trombositten zengin fibrin membranın kullanılması

Demir A., Olğun Erdikmen D., Altundağ Y., Tol Sevim Z.

VETERINARSKI ARHIV, cilt.92, sa.4, ss.443-458, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.24099/vet.archiv.1304
  • Dergi Adı: VETERINARSKI ARHIV
  • Derginin Tarandığı İndeksler: Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, EMBASE, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.443-458
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

The aim of this study was to evaluate the clinical efficacy of a platelet-rich fibrin (PRF) membrane, which is

considered to be a new alternative surgical method in the treatment of vision-threatening corneal ulcers in dogs.

Fourteen dogs (17 eyes) of various breeds and ages with deep corneal ulcers were treated surgically with a PRF

membrane transplantation. The corneal ulcer of all the patients was closed with an autologous platelet-rich fibrin

membrane. In the first 10 days after the operation, it was observed that the fibrin membrane partially melted, and

corneal epithelialization and granulation tissue occurred in and around the ulcer area due to the graft material. Pain

was significantly relieved, and conjunctival inflammation was noticeably improved. From the 20th day after the

surgery, the granulation tissue was gradually cleaned. It was determined that all the eyes had vision. The most common

complications after surgery were corneal pigmentation and fibrosis of varying severity. The use of autologous fibrin

membranes is a safe and effective surgical alternative for the closure and healing of corneal ulcers. Our findings show

that the autologous platelet-rich fibrin membrane is useful and effective in treating canine corneal deep ulcers.