IVSII-74 T > G: As harmless as we thought?

HOCAOGLU-EMRE F. S., Yenmis G., Saribal D., Yakicier C.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, sa.1, ss.41-46, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2018-0332
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.41-46
  • Anahtar Kelimeler: IVSII-74 T > G, beta-Globin gene, beta-Globin gene polymorphism, beta-Thalassemia, beta-Thalassemia carrier phenotype, BETA-GLOBIN GENE, HEMOGLOBIN-VARIANTS, THALASSEMIA MUTATIONS, POLYMORPHISMS, PHENOTYPE, SEQUENCE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: IVSII-74 T > G is one of the most frequently identified polymorphic sites on the beta-globin gene. In our report, we present three cases with low mean corpuscular volume (MCV) value in three and high red blood cell (RBC) value in two of the cases. The objective of this study was to further analyse the reason for condition of three patients, who were referred for the investigation of persistent anemia.