Expression of the <i>p53</i> and <i>nm23</i> genes in cholesteatoma
ACTA OTO-LARYNGOLOGICA, cilt.122, sa.7, ss.726-729, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 122 Sayı: 7
- Basım Tarihi: 2002
- Doi Numarası: 10.1080/003655402/000028050
- Dergi Adı: ACTA OTO-LARYNGOLOGICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.726-729
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Objective-To evaluate the roles of p53 and nm23 genes in cholesteatoma. Material and methods-The results of p53 and nm23 immunostainings were compared between 28 cholesteatoma samples and 13 control skin samples obtained from the external acoustic canal. Results-There were no correlations between p53 staining and either gender or type of cholesteatoma (p < 0.05). The mean numbers of p53-positive cells in the unpaired cholesteatoma and skin specimens were 23.1 ± 43.5 and 1 + 1.9, respectively and this difference was not statistically significant (z = -1.531; p = 0.2). The mean numbers of p53-positive cells in the paired cholesteatoma and skin specimens were 3.8 ± 6.1 and 29 ± 56.9, respectively and this difference was also not statistically significant (t = -1.078; p = 0.3). Cholesteatoma showed no nm23 positivity. Conclusion-The mechanisms relating to the expression of p53 and nm23 genes are not associated with the occurrence of cholesteatoma.