Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women
CANADIAN JOURNAL OF DIABETES, cilt.43, sa.3, ss.173-179, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.jcjd.2018.07.003
- Dergi Adı: CANADIAN JOURNAL OF DIABETES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.173-179
- Anahtar Kelimeler: antioxidants, gestational diabetes mellitus, intercellular adhesion molecule-1, lipid peroxidation, Lys469Glu polymorphism, redox homeostasis, OXIDATIVE STRESS, K469E POLYMORPHISM, ASSOCIATION, RETINOPATHY, PRODUCTS, DAMAGE, TESTS, IRON
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Also, we investigated whether this polymorphism could be associated with a change for better or worse as evidenced by clinical and redox biomarkers.