Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE (

Foessl, Ines; Bassett, J.; Bjornerem, Ashild; Busse, Bjoern; Calado, Angelo; Chavassieux, Pascale; Christou, Maria; Douni, Eleni; Fiedler, Imke; Fonseca, Joao; Hassler, Eva; Hoegler, Wolfgang; Kague, Erika; Karasik, David; Khashayar, Patricia; Langdahl, Bente; Leitch, Victoria; Lopes, Philippe; Markozannes, Georgios; McGuigan, Fiona; Medina-Gomez, Carolina; Ntzani, Evangelia; Oei, Ling; Ohlsson, Claes; Szulc, Pawel; Tobias, Jonathan; Trajanoska, Katerina; TÜZÜN, ŞANSIN; Valjevac, Amina; van Rietbergen, Bert; Williams, Graham; Zekic, Tatjana; Rivadeneira, Fernando; Obermayer-Pietsch, Barbara

doi:10.3389/fendo.2021.720728

Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")

Foessl I., Bassett J. H. D., Bjornerem A., Busse B., Calado A., Chavassieux P., ...Daha Fazla

FRONTIERS IN ENDOCRINOLOGY, cilt.12, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 12
Basım Tarihi: 2021
Doi Numarası: 10.3389/fendo.2021.720728
Dergi Adı: FRONTIERS IN ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
Anahtar Kelimeler: bone and skeletal diseases, phenotyping, imaging, animal models, GEMSTONE, COST, QUANTITATIVE COMPUTED-TOMOGRAPHY, REFERENCE POINT INDENTATION, MINERALIZATION DENSITY DISTRIBUTION, VERTEBRAL FRACTURE ASSESSMENT, BRANCHIAL ARCH MUTANTS, X-RAY ABSORPTIOMETRY, IN-VIVO ASSESSMENT, MECHANICAL-PROPERTIES, TURNOVER MARKERS, HIP FRACTURE
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals - including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing -omics data in order to advance musculoskeletal research and move towards "personalised medicine".