Spices to Control COVID-19 Symptoms: Yes, but Not Only ...

Bousquet J., Czarlewski W., Zuberbier T., Mullol J., Blain H., Cristol J., ...Daha Fazla

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, cilt.182, sa.6, ss.489-495, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 182 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1159/000513538
  • Dergi Adı: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.489-495
  • Anahtar Kelimeler: Nuclear factor (erythroid-derived 2)-like 2, Transient receptor potential ankyrin 1, Transient receptor potential vanillin 1, COVID-19, Spices, Fermented vegetables, HEALTH-BENEFITS, CHANNEL, NRF2, RECEPTOR, TRPA1, ACTIVATION, CAPSAICIN, DESENSITIZATION, ISOTHIOCYANATE, MODULATION
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. (c) 2020 S. Karger AG, Basel