The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

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Bayoglu B., Arslan C., Gode S., Dagistanli F., Arapi B., Deser S. B., ...Daha Fazla

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.21, sa.7, ss.659-671, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5551/jat.21774
  • Dergi Adı: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.659-671
  • Anahtar Kelimeler: Carotid atherosclerosis, CDKN2A, CDKN2BAS, Cell cycle, Gene expression, CHROMOSOME 9P21, NONCODING RNA, ANRIL, RISK, ATHEROSCLEROSIS, SUSCEPTIBILITY, DISEASE, LOCUS, MODULATION, PREVENTION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Aim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16(INK4a) inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression in vascular smooth muscle cells (VSMCs) and may modulate the early stages of atherosclerosis. Therefore, we aimed to study the expression of the INK4/ARF locus genes CDKN2A and CDKN2BAS in order to examine the p16INK4a protein expression and the level of cell proliferation in carotid plaques and saphenous tissue samples.