Losartan-induced hepatic injury
JOURNAL OF CLINICAL GASTROENTEROLOGY, cilt.34, sa.5, ss.585-586, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 5
- Basım Tarihi: 2002
- Doi Numarası: 10.1097/00004836-200205000-00022
- Dergi Adı: JOURNAL OF CLINICAL GASTROENTEROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.585-586
- Anahtar Kelimeler: losartan, hepatic injury, drug toxicity, INDUCED HEPATOTOXICITY, HYPERTENSION, HYDROCHLOROTHIAZIDE, TOLERABILITY, ANTAGONISTS, MANAGEMENT, POTASSIUM
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.