Combined impact of obstructive sleep apnea and periodic limb movements on sleep parameters

Park M., BENBİR ŞENEL G., Modi H., Jain V., DelRosso L. M.

Sleep Medicine, cilt.129, ss.339-345, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.sleep.2025.03.012
  • Dergi Adı: Sleep Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.339-345
  • Anahtar Kelimeler: Obstructive sleep apnea, Periodic limb movements of sleep, Polysomnography, Sleep fragmentation, Sleep quality
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Study objectives: This study examines the combined effects of Obstructive Sleep Apnea (OSA) and Periodic Limb Movements of Sleep (PLMS) on sleep parameters. Specifically, it aims to determine whether their co-occurrence exacerbates sleep fragmentation, reduces sleep efficiency, and alters restorative sleep stages compared to either condition alone. Methods: We retrospectively analyzed 581 adults undergoing polysomnography at UCSF Fresno. Subjects were categorized into three groups: OSA, PLMS, and OSA and PLMS. Sleep metrics, including Total Sleep Time (TST), Wake After Sleep Onset (WASO), and sleep stages (N1, N2, N3, REM), were compared across groups using Kruskal-Wallis tests and linear regression, adjusting for age. Results: The coexistence of OSA and PLMS was associated with a significant reduction in TST and a synergistic effect on deep sleep stages (N3) and REM, indicating amplified sleep disruption beyond additive effects. OSA and PLMS led to a marked increase in WASO and awakenings, although the impact on WASO was additive rather than synergistic. Conclusions: These findings underscore the need for tailored treatment approaches when OSA and PLMS co-occur. Standard OSA treatments like CPAP may be insufficient, as they don't address PLMS-induced sleep fragmentation. Effective management of both conditions could improve sleep quality and mitigate associated health risks.