THE SYNTHESIS AND CHARACTERIZATION OF NEW AMINOSUBSTITUTED AZANAPHTOQUINONE COMPOUNDS WITH ANTIMICROBIAL ACTIVITY


Bayrak N., Yıldırım H., Yıldız M., Tuyun A. F.

8 th International Conference on New Trends in Chemistry, Gazimagusa, Kıbrıs (Kktc), 16 - 18 Mayıs 2022, ss.66, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Gazimagusa
  • Basıldığı Ülke: Kıbrıs (Kktc)
  • Sayfa Sayıları: ss.66
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Organic compounds with a quinone skeleton, which stands out as a new class of inhibitors against various microorganisms, including Gram-positive/negative bacteria as well as fungi, have become the focus of attention by synthetic chemists and pharmacologists [1]. Many quinone compounds synthesized in previous studies by our group also showed impressive activities against bacteria and fungi [2-4]. In this study, new amino-substituted azanaphtoquinone analogs were synthesized from the nucleophilic reaction of halogenated azanaphtoquinone with amines containing different substituents at various positions of the aromatic ring, and the structures of the new compounds obtained were characterized by appropriate spectroscopic methods. In addition, the activities of these compounds against some Gram-negative, Gram-positive and fungal species were investigated.