THE SYNTHESIS AND CHARACTERIZATION OF NEW AMINOSUBSTITUTED AZANAPHTOQUINONE COMPOUNDS WITH ANTIMICROBIAL ACTIVITY
8 th International Conference on New Trends in Chemistry, Gazimagusa, Kıbrıs (Kktc), 16 - 18 Mayıs 2022, ss.66, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Gazimagusa
- Basıldığı Ülke: Kıbrıs (Kktc)
- Sayfa Sayıları: ss.66
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Organic compounds with a quinone skeleton, which stands out as a new class of inhibitors
against various microorganisms, including Gram-positive/negative bacteria as well as fungi,
have become the focus of attention by synthetic chemists and pharmacologists [1]. Many
quinone compounds synthesized in previous studies by our group also showed impressive
activities against bacteria and fungi [2-4].
In this study, new amino-substituted azanaphtoquinone analogs were synthesized from the
nucleophilic reaction of halogenated azanaphtoquinone with amines containing different
substituents at various positions of the aromatic ring, and the structures of the new
compounds obtained were characterized by appropriate spectroscopic methods. In addition,
the activities of these compounds against some Gram-negative, Gram-positive and fungal
species were investigated.