Telomeric DNA: Marker for human prostate cancer development?

ÖZEN, MUSTAFA; Imam, S.A.; Datar, R.H.; Multani , A.S.; Narayanan , A.R.; Chung , L.W.K.; von Eschenbach , A.C.; Pathak, S.

Telomeric DNA: Marker for human prostate cancer development?

ÖZEN M., Imam S., Datar R., Multani A., Narayanan A., Chung L., ...Daha Fazla

PROSTATE, cilt.36, sa.4, ss.264-271, 1998 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36 Sayı: 4
Basım Tarihi: 1998
Dergi Adı: PROSTATE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.264-271
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.