The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model

Evran S., ÇALIŞ F., Akkaya E., Baran O., Cevik S., Katar S., ...Daha Fazla

BRAIN RESEARCH BULLETIN, cilt.154, ss.68-80, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 154
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.brainresbull.2019.10.013
  • Dergi Adı: BRAIN RESEARCH BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.68-80
  • Anahtar Kelimeler: HMGB-1, Ocdudin, Traumatic brain injury, Bax, bcl-2, Brain edema, ISCHEMIA-REPERFUSION INJURY, TIGHT JUNCTION PROTEINS, ETHYL PYRUVATE, CYTOCHROME-C, HMGB1, RAGE, ACTIVATION, EXPRESSION, THERAPY, RELEASE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Traumatic brain injury (TBI) is one of the important reason of morbidity and mortality. While the primary injury due to mechanical impact is unavoidable, the secondary injury which is formed as a result of primary injury and thought to occur due to neurointlammation in the forefront can be prevented and by this way mortality and morbidity can be reduced. High mobility group box-1 (HMGB1) is a protein that triggers the neuroinflammatory process by being released from the nucleus of necrotic tissues after primary injury.