Changes in Markers of Ovarian Reserve After Laparoscopic Ovarian Cystectomy

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Ergun B., Ozsurmeli M., Dundar O., Comba C., Kuru O., Bodur S.

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, cilt.22, sa.6, ss.997-1003, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jmig.2015.05.001
  • Dergi Adı: JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.997-1003
  • Anahtar Kelimeler: Antimullerian hormone, Estradiol, Follicle-stimulating hormone, Laparoscopic ovarian cystectomy, Ovarian reserve, ANTI-MULLERIAN HORMONE, BILATERAL ENDOMETRIOMAS, DECLINE, EXCISION, IMPACT, CYSTS
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Study objective: This study was conducted to determine the changes in ovarian reserve markers after laparoscopic ovarian cystectomy (LOC).

Design: Prospective cohort study (Canadian Task Force classification II-2).

Setting: University teaching hospital.

Patients: Fifty 50 patients who underwent LOC were prospectively examined to determine the changes in serum markers of ovarian reserve, starting from 1 month before and 3 months after consecutive operations.

Interventions: Changes in serum markers were compared between the following groups: endometrioma cysts (n = 26) versus nonendometrioma cysts (n = 24), unilateral cystectomy (n = 38) versus bilateral cystectomy (n = 12), and bilateral endometrioma extirpation (n = 10) versus other cystectomy operations (n = 40).

Measurements and main results: A significant change was noticed between the preoperative and postoperative antimüllerian hormone (AMH) levels (2.67 ± 2.67 ng/mL vs 1.84 ± 1.72 ng/mL, p < .0001). Serum AMH levels were found to be significantly decreased in endometrioma (p = .002), nonendometrioma (p = .019), unilateral cystectomy (p = .001), bilateral cystectomy (p = .005), bilateral endometrioma (p = .011), and cysts other than bilateral endometrioma (p = .000) groups.

Conclusion: The ovarian reserve was found to be diminished after LOC regardless of the presence of endometrioma that could be distinguishable by serum AMH levels.