The No-Reflow Phenomenon as an Independent Predictor of Contrast-Induced Acute Kidney Injury and Mortality in STEMI Patients Undergoing Primary PCI
Catheterization and Cardiovascular Interventions, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/ccd.70904
- Dergi Adı: Catheterization and Cardiovascular Interventions
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: contrast-induced acute kidney injury, no-reflow phenomenon, pPCI, STEMİ, systemic inflammation
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Background: Contrast-induced acute kidney injury (CI-AKI) frequently complicates primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). The no-reflow phenomenon, a primary cause of inadequate reperfusion, is linked to systemic inflammation and CI-AKI development. Aims: This study evaluated the association between no-reflow and CI-AKI, and the subsequent impact on short- and long-term mortality. Methods: This prospective observational study included 299 STEMI patients undergoing primary PCI. CI-AKI was defined as a serum creatinine increase ≥ 25% or ≥0.5 mg/dL within 48–72 h post-contrast. No-reflow was diagnosed if final distal flow was