Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy.
Metabolism: clinical and experimental, cilt.65, ss.1466-77, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 65
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.metabol.2016.06.010
- Dergi Adı: Metabolism: clinical and experimental
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1466-77
- Anahtar Kelimeler: Experimental diabetic nephropathy, Ku70, Apoptosis, TUBULAR EPITHELIAL-CELLS, RENIN-ANGIOTENSIN SYSTEM, ACE-INHIBITION, IV COLLAGEN, DNA-DAMAGE, EXPRESSION, RATS, IRBESARTAN, RECEPTOR, BAX
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Background. Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats.