Akademik Veri Yönetim Sistemi
7th Asia Pacific International Modern Sciences Congress, Jakarta, Endonezya, 4 - 05 Kasım 2022, ss.159, (Özet Bildiri)
Alzheimer's disease (AD) is a progressive neurologic disorder and affects multiple brain functions
such as memory loss and other cognitive abilities serious enough to interfere with daily life. In
Alzheimer's disease, changes occur in many organs of the body. The liver is one of the organs
affected in Alzheimer's disease. The aim of the present study was to evaluate the possible protective
effects of Petroselinum crispum (PC) on liver damage in the scopolamine-induced AD rat model. In
this study, Wistar albino rats were divided into four groups: Control (C), scopolamine (Scop, 1
mg/kg, i.p.) and, galantamine (GAL, 1.5 mg/kg, i.p.) and PC extract (2 g /kg, p.o.)-treated
scopolamine (PC) groups. GAL and PC extract were administered for 14 days. At the end of the
study, the rats were euthanatized and liver tissues were taken and homogenized in physiological
saline. The glutathione (GSH), lipid peroxidation (LPO), interleukin-1β (IL-1β), interleukin-6 (IL6) and tumor necrosis factor alpha (TNF-α) levels and alanine aminotransferase (ALT), aspartate
aminotransferase (AST), sorbitol dehydrogenase (SDH) and myeloperoxidase (MPO) activities
were estimated in liver homogenates. According to the results, GSH levels were found to decreased
while LPO, IL-1β, IL-6 and TNF-α levels and ALT, AST, SDH and MPO activities were increased
in the Scop group as compared to control group. Administration of the GAL and PC reversed these
effects. In this study, it was observed that the PC extract prevented the liver damage caused
scopolamine-induced AD.