Effects of resveratrol on high-fructose-induced testis injury in rats
ULTRASTRUCTURAL PATHOLOGY, cilt.42, sa.1, ss.65-73, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/01913123.2017.1397075
- Dergi Adı: ULTRASTRUCTURAL PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.65-73
- Anahtar Kelimeler: Apoptosis, electron microscopy, high-fructose diet, resveratrol, testis, INHIBIN-B LEVELS, METABOLIC SYNDROME, OXIDATIVE STRESS, INSULIN-RESISTANCE, SERTOLI-CELLS, HIGH-CALORIE, MEN, OBESITY, MICE, SPERMATOGENESIS
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr-fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index.